SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cellsSARS-CoV-2 Omicron 변이체는 TMPRSS2 발현 세포에서 Delta 변이체와 비교할 때 복제 및 융합 활성이 덜 효율적입니다.Comparative Study Published on 2022-01-192022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] Affect Antiviral effect B.1.1.529 bafilomycin Calu3 CaLu3 cells camostat Cell cell line cells Characteristics Chloroquine clinical manifestation clinical manifestations competition Delta delta variant Delta variants disease severity Endocytic pathway entry pathway Immune escape Infection inhibit inhibited inhibiting less mutations not enhanced omicron Omicron variant replicated Replication robust SARS-CoV-2 Serine TMPRSS2 TMPRSS2 expression TMPRSS2 pathway transmembrane serine protease transmembrane serine protease 2 Transmissibility variant variants viral replication Virological [DOI] 10.1080/22221751.2021.2023329 PMC 바로가기 [Article Type] Comparative Study
Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2SARS-CoV-2 진입의 Hydroxychloroquine 매개 억제는 TMPRSS2에 의해 약화됩니다Research Article Published on 2021-01-192022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, [키워드] ablated activate activated activating antiviral activities antiviral activity Autoimmune disorders block cathepsin L Cathepsins cause Cell cell entry cell surface cell-culture studies cell-culture systems Chloroquine cleave clinically Combination combinations coronavirus COVID-19 COVID-19 patient dependent on Efficacy endocytosis Endosomal acidification endosomal protease explain functional furin furin cleavage site furin-cleavage site global public health human clinical trial human clinical trials Hydroxychloroquine identify in vivo Infection inhibit inhibit SARS-CoV-2 interfere introduced lack malaria membrane fusion observé pathogenic coronavirus pathway plasma plasma membrane Prevent protease TMPRSS2 Protein Proteins proteolytic activity Receptor binding reversed S protein S proteins SARS Coronavirus SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike shown target cell target cells tested the cell the SARS-CoV-2 these compounds TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor TMPRSS2 pathway treat treated treatment for COVID-19 utility Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1009212 PMC 바로가기 [Article Type] Research Article